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Related Experiment Video

Updated: Mar 15, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

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Dynamic Liver Function Tests in Paediatric Liver Disease.

Thora Wesenberg Helt¹, Jon Nielsen², Gabriella Ficerai-Garland³

¹Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.

Diagnostics (Basel, Switzerland)

|March 14, 2026

Summary

This summary is machine-generated.

Dynamic liver function tests, indocyanine green (ICG) clearance and hepatobiliary scintigraphy (HBS), correlate well in children with liver disease. These tests offer valuable insights into liver function and disease markers.

Keywords:

hepatobiliary scintigraphy indocyanine green clearance liver function paediatric liver disease

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Area of Science:

Pediatric Gastroenterology and Hepatology
Diagnostic Imaging and Nuclear Medicine

Background:

Accurate assessment of pediatric liver function is challenging.
Conventional liver function tests may not reflect disease severity in children.
Dynamic tests like indocyanine green (ICG) clearance and hepatobiliary scintigraphy (HBS) show promise.

Purpose of the Study:

To evaluate the correlation between ICG clearance and HBS in pediatric liver disease.
To identify liver disease markers associated with ICG clearance and HBS.
To assess the utility of dynamic liver function tests in children.

Main Methods:

Study included 131 children (0-18 years) with liver disease or after liver transplantation (LTx).
All participants underwent ICG clearance and HBS assessments.
Data collected between November 2015 and August 2024.

Main Results:

ICG clearance and HBS demonstrated a significant correlation.
Both tests were associated with liver injury, cholestasis, cirrhosis, and portal hypertension.
ICG clearance uniquely correlated with portal blood flow; LTx impacted HBS but not ICG clearance.

Conclusions:

ICG clearance and HBS are correlated and valuable for assessing liver function in children.
These dynamic tests align with various conventional liver function markers.
Further research is needed to establish the predictive value of ICG clearance and HBS in disease progression.