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Updated: Mar 30, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Strong Notch activation hinders bevacizumab efficacy in advanced colorectal cancer
Francesca V Negri1, Pellegrino Crafa2, Giuseppe Pedrazzi3
1Medical Oncology Unit, University Hospital, Via Gramsci 14, 43126 Parma, Italy.
Aim:
To assess the role of Notch activation in predicting bevacizumab efficacy in colorectal cancer (CRC).
Materials & Methods:
Notch activation was evaluated by immunohistochemistry (IHC) on 65 CRC enrolled within randomized clinical trials assessing first-line bevacizumab-based chemotherapy and on 21 CRC treated with chemotherapy alone.
Results:
Strong Notch (IHC 3+) activation was negatively associated with response (18 vs 62% in low Notch cases [IHC 0, 1, 2+]; p = 0.016), progression-free survival (4.9 vs 12.1 months; p = 0.002) and overall survival (19.3 vs 30.4 months; p = 0.039). No correlation was found between Notch activation and clinical outcome in CRC treated with chemotherapy alone.
Conclusion:
A potential role of Notch activation in the antitumor activity of bevacizumab could be hypothesized.
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