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Updated: Mar 30, 2026
Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
Published on: April 5, 2019
Seronegative neuromyelitis optica spectrum disorder patients diagnosed using new diagnostic criteria
Akiyuki Uzawa1, Masahiro Mori2, Tomohiko Uchida2
1Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan auzawa@chiba-u.jp.
Background:
Recently, new diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD) were published.
Objective:
Our primary aim was to evaluate the usefulness of the new diagnostic criteria in anti-aquaporin 4 (AQP4) antibody-negative cases.
Methods:
Consecutive 471 patients whose anti-AQP4 antibody was measured at Chiba University were reviewed.
Results:
Four anti-AQP4 antibody negative-patients, who fulfilled the new diagnostic criteria for NMOSD but not 2006 diagnostic criteria for neuromyelitis optica (NMO), were identified. They showed high cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels, an absence of oligoclonal bands and/or cloud-like enhancement on magnetic resonance imaging, which are compatible findings for NMO.
Conclusion:
The new diagnostic criteria are clinically useful in seronegative NMOSD.
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