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Updated: Sep 7, 2026
Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
Published on: November 18, 2019
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue
Qiuyun Yang1,2, Jinghe Zhao3, Manhua Cui1
1Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Aim:
Recent studies have demonstrated that the neural precursor cell expressed, developmentally downregulated 4-like (Nedd4L) gene plays a role in the progression of various cancers. However, reports describing Nedd4L expression in ovarian cancer tissues are limited.
Material And Methods:
A cohort (n = 117) of archival formalin-fixed, paraffin embedded resected normal ovarian epithelial tissues (n = 10), benign ovarian epithelial tumor tissues (n = 10), serous borderline ovarian epithelial tumor tissues (n = 14), mucous borderline ovarian epithelial tumor tissues (n = 11), and invasive ovarian epithelial cancer tissues (n = 72) were assessed for Nedd4L protein expression using immunohistochemistry.
Results:
Nedd4L protein expression was significantly decreased in invasive ovarian epithelial cancer tissues compared to non-cancer tissues (P < 0.05). Decreased Nedd4L protein expression correlated with clinical stage, pathological grade, lymph node metastasis and survival (P < 0.05).
Conclusion:
Nedd4L protein expression may be an independent prognostic marker of ovarian cancer development.
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