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Zn-Mediated Reduction of Oxalyl Chloride Forming CO and Its Application in Carbonylation Reactions
Martin Markovič1, Pavol Lopatka1, Peter Koóš2
1Department of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology , Radlinského 9, SK-812 37 Bratislava, Slovakia.
Abstract:
An efficient protocol for the generation of carbon monoxide by Zn-mediated reduction of oxalyl chloride has been developed. Oxalyl chloride was applied as an extremely effective substitute for toxic gaseous CO in the palladium-catalyzed alkoxy-/amino-/hydrogen-/hydroxycarbonylation processes providing industrially interesting esters, amides, aldehydes, and carboxylic acids in good to excellent yields. This new procedure can be applied to various carbonylation reactions in the presence of a transition metal catalyst under mild conditions and with a stoichiometric amount of CO source.
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