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Emerging Trends in Noninvasive Insulin Delivery
Arun Verma1, Nitin Kumar1, Rishabha Malviya1
1Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Yamuna Expressway, Greater Noida, Uttar Pradesh, India.
Journal of Pharmaceutics
|November 12, 2015
Summary
Developing oral insulin delivery systems aims to overcome the drawbacks of injections for diabetes management. Research focuses on overcoming enzymatic degradation and improving formulation for this convenient administration route.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Biotechnology
Background:
- Diabetes mellitus is a metabolic disorder characterized by hyperglycemia.
- Current insulin administration relies on subcutaneous injections, which can cause pain, anxiety, and infection.
- Oral insulin delivery offers a more convenient and patient-friendly alternative.
Purpose of the Study:
- To review advancements in oral insulin delivery systems.
- To discuss formulation strategies for oral insulin.
- To highlight the potential of oral insulin to improve diabetes treatment.
Main Methods:
- Literature review of existing research on oral insulin delivery.
- Analysis of formulation techniques and components.
- Examination of methods to protect insulin from enzymatic degradation.
Main Results:
- Various enzyme inhibitors (e.g., sodium cholate, camostat) have been investigated to prevent insulin degradation.
- Different formulation approaches are being explored to enhance oral bioavailability.
- The oral route promises to eliminate injection-related pain and anxiety.
Conclusions:
- Oral insulin delivery systems are under active research and development.
- Successful oral insulin formulations could significantly improve the quality of life for individuals with diabetes.
- Continued research into formulation and delivery mechanisms is crucial for clinical application.
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