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Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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OsteoRheumatology: a new discipline?

Marta Favero1, Andrea Giusti2, Piet Geusens3

  • 1Rheumatology Unit, Department of Medicine-DIMED , University Hospital of Padova , Padova , Italy ; Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES , Rizzoli Orthopedic Research Institute , Bologna , Italy.

RMD Open
|November 12, 2015
PubMed
Summary
This summary is machine-generated.

This review highlights the critical interplay between bone, immune system, and cartilage in rheumatic diseases like osteoarthritis. Understanding these interactions is key for developing new treatments for disabling musculoskeletal conditions.

Keywords:
OsteoarthritisOsteoporosisRheumatoid ArthritisSpondyloarthritisTreatment

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Area of Science:

  • Rheumatology and Immunology
  • Orthopedics and Bone Biology

Background:

  • Disabling rheumatic diseases such as osteoarthritis, rheumatoid arthritis, and spondyloarthritis involve complex interactions between bone, immune system, and cartilage.
  • Recent advancements necessitate a deeper understanding of these interconnected biological systems.

Purpose of the Study:

  • To review current evidence on the bone-immune-cartilage axis in rheumatic diseases.
  • To discuss emerging knowledge and novel therapeutic strategies targeting underlying pathophysiological processes.
  • To highlight the need for integrated research and clinical approaches.

Main Methods:

  • Literature review of recent evidence presented at the 'OsteoRheumatology' conference.
  • Synthesis of expert discussions on the role of bone tissue in rheumatic diseases.
  • Focus on new treatments derived from understanding pathophysiological mechanisms.

Main Results:

  • The review emphasizes the intricate relationship between bone, immune cells, and cartilage in the pathogenesis of rheumatic conditions.
  • Emerging treatments are being developed based on a more profound comprehension of these interactions.
  • Significant gaps in knowledge persist, underscoring the need for further investigation.

Conclusions:

  • A comprehensive understanding of the cartilage-immune system-bone interactions is crucial for both clinical practice and research in rheumatic diseases.
  • 'OsteoRheumatology' emerges as a potential interdisciplinary field to address these complex challenges.
  • Further research is essential to unravel the multifactorial nature of common and disabling rheumatic diseases.