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Related Concept Videos

Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
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Related Experiment Video

Updated: Mar 30, 2026

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry LCM-LC/MS
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Low level nitrogen laser therapy in pulmonary tuberculosis.

N S Bhagwanani1, C C Bhatia1, N Sharma1

  • 1Choithram Hospital and Research Centre, Indore (M.P).

Laser Therapy
|November 12, 2015
PubMed
Summary

This study found that intra-cavitary N2 laser therapy shows significant success when used alongside chemotherapy for treating multi-drug resistant tuberculosis (TB). The N2 laser demonstrated a bactericidal effect in vitro and improved patient outcomes.

Keywords:
Multi drug resistant tuberculosisNitrogen LaserTreatmentTuberculosis

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Area of Science:

  • Medical Microbiology
  • Laser Physics
  • Pulmonology

Background:

  • Tuberculosis (TB) remains a global health challenge, with millions of new cases and deaths annually.
  • Multi-drug resistant tuberculosis (MDR-TB) presents a significant treatment challenge due to high mortality rates.
  • A substantial proportion of MDR-TB cases are concentrated in India, China, and the Russian Federation.

Purpose of the Study:

  • To determine the prevalence of drug resistance in Mycobacterium tuberculosis isolates in Central India.
  • To evaluate the in-vitro efficacy of N2 laser against M. tuberculosis.
  • To assess the therapeutic impact of intra-cavitary N2 laser irradiation on pulmonary TB patients unresponsive to chemotherapy.

Main Methods:

  • Drug sensitivity testing was performed on 567 M. tuberculosis isolates using the proportion method.
  • In-vitro N2 laser efficacy was assessed by exposing M. tuberculosis cultures on LJ plates to laser irradiation for 10 minutes.
  • Intra-cavitary laser therapy involved introducing a fiber into the lung cavity for 10 minutes of N2 laser irradiation.

Main Results:

  • Only 12.8% of M. tuberculosis isolates were sensitive to all anti-TB drugs; 21.5% exhibited resistance to Rifampicin, meeting the definition of MDR-TB.
  • In-vitro studies confirmed a bactericidal effect of N2 laser on M. tuberculosis.
  • In a clinical trial, 90% of 96 patients showed improvement, with 60% exhibiting improved X-rays and 75% becoming Acid-fast bacilli smear-negative within 4-15 days.

Conclusions:

  • Intra-cavitary N2 laser therapy is a highly effective adjunct to conventional chemotherapy for treating pulmonary tuberculosis.
  • The study highlights the potential of N2 laser as an innovative therapeutic modality for challenging TB cases.