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Updated: Mar 30, 2026
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
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Optimizing the initial choice and timing of therapy in relapsing-remitting multiple sclerosis
Rebecca S Farber1, Ilana K Sand2
1Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Therapeutic Advances in Neurological Disorders
|November 12, 2015
Summary
Choosing initial therapy for relapsing multiple sclerosis (MS) requires careful consideration of drug risk-benefit profiles and individual patient factors. Early initiation of disease-modifying therapy (DMT) is generally recommended for relapse prevention and mitigating neurodegeneration.
Area of Science:
- Neurology
- Immunology
- Pharmacology
Background:
- Multiple sclerosis (MS) treatment landscape includes 12 US Food and Drug Administration-approved medications.
- Selecting initial therapy for relapsing MS is complex due to diverse risk-benefit profiles and patient individuality.
Purpose of the Study:
- To outline key considerations for selecting initial disease-modifying therapy (DMT) in relapsing multiple sclerosis.
- To emphasize the importance of a personalized approach in DMT selection.
Main Methods:
- Review of clinical trial data for assessing drug efficacy.
- Analysis of safety profiles, including known and potential risks.
- Consideration of patient-specific factors: disease characteristics, comorbidities, reproductive plans, and preferences.
Main Results:
- No simple algorithm exists for initial MS therapy selection.
- Efficacy data are limited by lack of direct comparisons and predictive biomarkers.
- Safety, tolerability, and patient-specific factors are crucial in decision-making.
Conclusions:
- Physicians must weigh multiple factors, including treatment efficacy, safety, tolerability, and patient-specific needs.
- Early initiation of DMT is generally recommended to prevent relapses and neurodegeneration, despite uncertainties in long-term benefits.
- Personalized treatment strategies are essential for managing relapsing multiple sclerosis effectively.
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