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Bioinspired pH and magnetic responsive catechol-functionalized chitosan hydrogels with tunable elastic properties.

Ali Ghadban1, Anansa S Ahmed2, Yuan Ping1

  • 1School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. ali.miserez@ntu.edu.sg and Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore.

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Researchers created smart hydrogels that respond to pH and magnetic fields. These advanced materials offer tunable drug delivery and mechanical properties for versatile applications.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Hydrogels are versatile biomaterials with applications in drug delivery and tissue engineering.
  • Stimuli-responsive hydrogels offer dynamic control over material properties.
  • Developing multi-responsive hydrogels with tunable characteristics remains a key challenge.

Purpose of the Study:

  • To develop novel pH- and magnetic-responsive hydrogels.
  • To investigate the role of catechol/Fe(3+) ligands and complexation valence on hydrogel properties.
  • To explore the potential of these hydrogels for controlled drug release applications.

Main Methods:

  • Synthesis of hydrogels stabilized by covalent bonding and catechol/Fe(3+) coordination.
  • Characterization of viscoelastic properties and their modulation by complexation valence.
  • Incorporation of magnetic nanoparticles to impart magnetic responsiveness.
  • Evaluation of drug release profiles under varying pH and magnetic field conditions.

Main Results:

  • Successfully developed dual pH- and magnetic-responsive hydrogels.
  • Demonstrated that complexation valence precisely regulates viscoelastic properties.
  • Showcased tunable drug release kinetics influenced by stimuli.
  • Confirmed enhanced control over mechanical response and drug release via magnetic nanoparticles.

Conclusions:

  • The developed hydrogels exhibit tunable properties and dual stimuli-responsiveness.
  • These materials offer a promising platform for advanced drug delivery systems.
  • The combination of covalent and coordination crosslinking provides robust control over hydrogel performance.