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Mal de debarquement syndrome: a systematic review
Angelique Van Ombergen1,2,3, Vincent Van Rompaey4,5, Leen K Maes6,7,8
1Antwerp University Research Centre for Equilibrium and Aerospace (AUREA), University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium. angelique.vanombergen@uantwerpen.be.
Journal of Neurology
|November 13, 2015
Summary
Mal de debarquement syndrome (MdDS) causes persistent motion perception after travel. This systematic review highlights diagnostic needs and calls for research into MdDS prevalence, pathophysiology, and effective treatments.
Area of Science:
- Neuroscience
- Vestibular Disorders
- Human Physiology
Background:
- Mal de debarquement (MdD) is a common, transient sensation of self-motion after passive motion exposure, typically sea travel.
- Mal de debarquement syndrome (MdDS) is a persistent form of MdD, affecting individuals long after the initial exposure.
- The pathophysiology of MdDS remains poorly understood, leading to limited treatment options.
Purpose of the Study:
- To conduct a systematic literature review on Mal de debarquement (MdD) and Mal de debarquement syndrome (MdDS).
- To identify shortcomings in current MdDS research and propose diagnostic criteria.
- To guide future research directions for MdDS.
Main Methods:
- Systematic search of medical databases using terms 'mal de debarquement' and 'sea legs'.
- Inclusion and exclusion of studies based on predefined criteria.
- Analysis of existing literature to synthesize findings and identify research gaps.
Main Results:
- A growing body of literature indicates increased interest in MdDS.
- Current literature lacks a systematic review, hindering a comprehensive understanding.
- Proposed diagnostic criteria are suggested to aid healthcare professionals.
Conclusions:
- A systematic review is crucial to address current literature gaps in MdDS.
- Further research is needed to determine MdDS prevalence and underlying pathophysiology.
- Prospective, randomized, placebo-controlled trials are essential for evaluating treatment efficacy.

