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Updated: Feb 10, 2026

Fiber Optic Distributed Sensors for High-resolution Temperature Field Mapping
Published on: November 7, 2016
Femtoliter-scale optical nanofiber sensors
Abstract:
We report a robust and sensitive optical nanofiber sensor with a femtoliter-scale detection volume. The sensor is fabricated by embedding a 800-nm-diameter nanofiber into a microfluidic chip with probing light propagated perpendicular to a 5-μm-wide detection channel. To verify the effectiveness of the sensor, we present measurements of fluorescence intensity and refractive index (RI) with detection limits of 1 × 10(-7) M for fluorescein and 2.8 × 10(-4) RIU, respectively. The femtoliter-scale optical nanofiber sensor shown here may provide a compact and versatile sensing platform for sensitive and fast detection of ultra-low-volume samples, as well as studying the dynamics of single molecule.
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