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Updated: Mar 30, 2026

A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
An analysis of the clinical trial landscape for cutaneous melanoma
Sara Harcharik Perkins, Kristian D Stensland, Matthew D Galsky
1Ann B. Barshinger Cancer Institute, 2102 Harrisburg Pike, Lancaster, PA 17601, USA. shanthisivendran@gmail.com.
Abstract:
Recognizing current trends and obstacles in melanoma clinical trial development is critical to future progress in this field. This article examines the melanoma research enterprise to identify changing trends and potential barriers to success. All trials registered at ClinicalTrials.gov after September 2005 were evaluated for possible inclusion. A total of 777 interventional trials designed specifically for cutaneous melanoma patients were included. Geographic trial distribution as well as disease state and type of intervention were analyzed and compared among each group. ClinicalTrials.gov is an invaluable tool to study the research enterprise. Further studies are needed on prevention and early detection of melanoma in the curative setting, a critical role for dermatologists.
Insights
Analyzing melanoma clinical trials reveals trends and challenges. Future research should focus on prevention and early detection, areas where dermatologists play a crucial role.
Area of Science:
- Oncology
- Clinical Research
- Dermatology
Background:
- Melanoma clinical trial development faces evolving trends and obstacles.
- Understanding these dynamics is crucial for advancing melanoma research.
- The study examines the melanoma research landscape to identify key shifts and potential barriers.
Purpose of the Study:
- To analyze current trends in melanoma clinical trial development.
- To identify potential barriers hindering progress in melanoma research.
- To provide insights for future melanoma research strategies.
Main Methods:
- Evaluated all interventional trials for cutaneous melanoma registered at ClinicalTrials.gov after September 2005.
- Included a total of 777 interventional trials.
- Analyzed and compared geographic trial distribution, disease state, and intervention types.
Main Results:
- ClinicalTrials.gov serves as a vital resource for studying the research landscape.
- Identified trends and barriers in melanoma clinical trial development.
- Geographic distribution, disease state, and intervention types were key areas of analysis.
Conclusions:
- Further research is essential for melanoma prevention and early detection.
- Dermatologists have a critical role in the curative setting for melanoma.
- Recognizing trends and obstacles is key to improving future melanoma clinical trials.
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