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Inotropic effects of endothelin in ferret ventricular myocardium
A M Shah1, M J Lewis, A H Henderson
1Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
European Journal of Pharmacology
|April 25, 1989
Abstract:
The characteristics of the inotropic response to endothelin were studied in isolated ferret papillary muscle preparations. Endothelin (0.1-10 nM) induced concentration-dependent positive inotropic effects. At 10 nM, isometric tension increased by 17%, maximum rate of tension development by 18%, maximum velocity of unloaded shortening by 23% and peak isotonic shortening by 11%. Time to peak isometric tension and half isometric relaxation time were unaltered by endothelin. This pattern of change is similar to that of elevating extracellular calcium concentration.