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Acquired neurocutaneous disorders.

Amre Nouh1, Jodi Speiser2, José Biller3

  • 1Department of Neurology, Hartford Hospital - University of Connecticut, Hartford CT, USA.

Handbook of Clinical Neurology
|November 14, 2015
PubMed
Summary

Neurologic diseases often present with skin symptoms, influenced by genetic and autoimmune factors. This review covers congenital, genetic, and acquired neurocutaneous disorders, including Behcet's disease and lupus.

Keywords:
Behçet's diseaseNeurologic manifestationsParry–Romberg syndrome and Degos diseaseSjögren syndromedermatologic manifestationsdermatomyositissclerodermasystemic lupus erythematosus (SLE)

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Area of Science:

  • Neurology
  • Dermatology
  • Genetics

Background:

  • Neurologic diseases frequently exhibit cutaneous manifestations.
  • These skin findings can appear before, during, or after neurological symptoms.
  • Autoimmune, genetic, and environmental factors influence neurocutaneous disorder presentation.

Purpose of the Study:

  • To review neurocutaneous disorders, focusing on congenital and genetic conditions.
  • To discuss the pathophysiology and clinical manifestations of acquired neurocutaneous disorders.
  • To highlight specific examples such as Behcet's disease, dermatomyositis, and lupus.

Main Methods:

  • Literature review of neurocutaneous disorders.
  • Emphasis on congenital and genetic conditions.
  • Discussion of acquired disorders including specific autoimmune diseases.

Main Results:

  • Neurocutaneous disorders encompass a wide range of conditions.
  • Congenital and genetic factors are significant in many cases.
  • Acquired conditions like Behcet's disease, dermatomyositis, Sjögren's syndrome, lupus, scleroderma, Parry-Romberg syndrome, and Degos disease are discussed.

Conclusions:

  • Understanding the link between neurologic and cutaneous findings is crucial.
  • Both genetic and acquired factors contribute to neurocutaneous diseases.
  • This review provides a comprehensive overview of various neurocutaneous conditions.