Related Experiment Video

Updated: Mar 30, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.9K

Consanguinity ratio in b-thalassemia major patients in District Bannu

Muhammad Sadiq Khan1, Mushtaq Ahmed1, Rahmat Ali Khan1

  • 1Department of Biotechnology, University of Science and Technology, KPK, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|November 14, 2015
PubMed

Insights

Consanguineous marriages are frequent in beta-thalassemia major patients in Pakistan. This genetic factor likely contributes to the high prevalence of beta-thalassemia major in the study region.

Area of Science:

  • Medical Genetics
  • Public Health

Background:

  • Beta-thalassemia major is a severe inherited blood disorder.
  • Consanguinity, or marriage between relatives, increases the risk of autosomal recessive genetic disorders.

Purpose of the Study:

  • To determine the rate of consanguinity among patients with beta-thalassemia major.
  • To investigate the relationship between consanguinity and factors like age, gender, and Hepatitis C virus (HCV) antibody status in these patients.

Main Methods:

  • A cross-sectional study was conducted in Bannu district, Pakistan, from June 2013 to July 2014.
  • Data on 180 beta-thalassemia major patients were collected using questionnaires.

Main Results:

  • Consanguinity was observed in 74% of patients' parents (133 out of 180).
  • The prevalence of anti-HCV antibody positivity was 7.77% (14 out of 180 patients).

Conclusions:

  • The high incidence of beta-thalassemia major in the study area is strongly linked to consanguineous marriages.
  • Consanguinity is a significant risk factor for beta-thalassemia major in this population.
Abstract

Keywords:
Beta Thalassemia Major, Hepatitis C, Consanguinity, Bannu.

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah04:43

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah

Published on: June 24, 2025

603

Related Concept Videos

Probability Laws01:49

Probability Laws

Overview
44.9K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.4K
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
38.8K
Pedigree Analysis01:35

Pedigree Analysis

Overview
90.8K
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.9K
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
24.4K