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Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models
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Actions of thrombin in the interstitium

G G de Ridder1, R L Lundblad2, S V Pizzo1

  • 1Department of Pathology, Duke University Medical Center, Durham, NC, USA.

Journal of Thrombosis and Haemostasis : JTH
|November 14, 2015
PubMed

Thrombin is a pleiotropic enzyme best known for its contribution to fibrin formation and platelet aggregation during vascular hemostasis. There is increasing evidence to suggest a role for thrombin in the development of interstitial fibrosis, but interstitial thrombin has not been demonstrated by the direct determination of activity. Rather its presence is inferred by products of thrombin action such as fibrin and activated fibroblasts. This review will focus on possible mechanisms of thrombin formation in the interstitial space, the possible actions of thrombin, processes regulating thrombin activity in the interstitial space, and evidence supporting a role for thrombin in fibrosis.

Keywords:
antithrombin IIIblood coagulation factorfactor Xafibrosisprothrombinthrombin

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