Related Experiment Video

Updated: Mar 30, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K

[Risk factors of 125 cases of neonatal congenital hypothyroidism during perinatal period]

Jinfu Zhou1, Jinying Luo2, Hong Zhao1

  • 1Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|November 14, 2015
PubMed

Insights

Maternal age, gestational diabetes, and thyroid issues are key risk factors for congenital hypothyroidism (CH). Perinatal care improvements can help reduce CH incidence in newborns.

Area of Science:

  • Neonatal Health
  • Endocrinology
  • Perinatal Medicine

Background:

  • Congenital hypothyroidism (CH) is a significant cause of preventable intellectual disability in newborns.
  • Understanding perinatal risk factors is crucial for developing effective prevention strategies.

Purpose of the Study:

  • To investigate the association between various perinatal factors and the occurrence of congenital hypothyroidism (CH).
  • To provide scientific evidence to guide the prevention of CH.

Main Methods:

  • A case-control study was conducted involving 125 neonates with CH and 375 controls.
  • Logistic regression analysis (univariate and multivariate) was used to identify perinatal risk factors for CH.

Main Results:

  • Advanced maternal age, gestational diabetes mellitus, and maternal thyroid disease were identified as significant risk factors.
  • Preterm birth, low birth weight, macrosomia, multiple gestation, birth defects, and fetal distress also increased CH risk.

Conclusions:

  • CH is associated with maternal age, gestational diabetes, gestational thyroid disease, and neonatal factors like birth weight and gestational age.
  • Enhanced perinatal care focusing on identified risk factors is recommended to decrease CH incidence.
Abstract

More Related Videos

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

11.0K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.4K

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.9K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.4K
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
37