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Related Concept Videos

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Dogs as a Model for Cancer.

Heather L Gardner1, Joelle M Fenger1, Cheryl A London1,2

  • 1Department of Veterinary Clinical Sciences and.

Annual Review of Animal Biosciences
|November 14, 2015
PubMed
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Client-owned dogs with cancer serve as a valuable preclinical model, mirroring human cancers. This approach accelerates cancer drug development, benefiting both pets and people by optimizing therapies before human trials.

Keywords:
cancerclinical trialscomparative oncologydogpreclinical model

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Area of Science:

  • Comparative oncology
  • Translational cancer research
  • Veterinary medicine

Background:

  • Spontaneous canine cancers closely mimic human malignancies in clinical and molecular aspects.
  • Dogs with cancer offer a naturally occurring model for studying cancer progression and therapeutic responses.

Purpose of the Study:

  • To highlight the utility of canine cancer models in preclinical drug development.
  • To emphasize how studying dog cancers can optimize cancer therapeutics for human clinical trials.

Main Methods:

  • Leveraging spontaneous canine cancers as a translational research model.
  • Analyzing clinical presentation, histology, molecular profiles, and treatment responses in dogs.
  • Establishing pharmacokinetic/pharmacodynamic relationships and identifying toxicities in canine cancer patients.

Main Results:

  • Canine cancer models have successfully informed the development of cancer therapeutics.
  • This model aids in predicting drug efficacy, toxicity, and resistance mechanisms.
  • Early elimination of ineffective therapies and optimization of promising treatments are facilitated.

Conclusions:

  • Integrating dogs into preclinical cancer research accelerates the development of effective cancer drugs.
  • This comparative oncology approach benefits both animal and human health by improving treatment outcomes.
  • Further understanding of canine cancer molecular drivers presents unique opportunities for drug development.