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Adverse effects of fenfluramine in treatment refractory schizophrenia
B D Marshall1, S M Glynn, K K Midha
1Department of Psychology, University of California, Los Angeles.
Journal of Clinical Psychopharmacology
|April 1, 1989
Abstract:
Fenfluramine was administered to eight severely ill schizophrenic patients as an adjunct to neuroleptic drugs in a double-blind, multiple baseline design. A significant adverse effect of fenfluramine on psychopathology was detected through nurses' ratings, target symptom scales, the Brief Psychiatric Rating Scale, and time-sampled behavioral observations. Clinical deterioration was correlated with fenfluramine-induced reductions in blood serotonin levels and persisted beyond the point of discontinuation of fenfluramine.