Related Experiment Video

Updated: Mar 30, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

17.0K

Gout, not hyperuricemia alone, impairs left ventricular diastolic function

Jing-Chi Lin1,2, Chun-Liang Lin3,4, Mien-Cheng Chen5

  • 1Division of Allergy and Immunology and Rheumatology, Chang Gung Memorial Hospital, Chiayi, Taiwan. jingchilin@gmail.com.

Arthritis Research & Therapy
|November 17, 2015
PubMed

Insights

Gout is linked to left ventricular diastolic dysfunction and enlarged left atrial volume, independent of hyperuricemia alone. This study highlights gout

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Rheumatology

Background:

  • Gout, a metabolic disorder marked by hyperuricemia and inflammation, is associated with cardiovascular disease and left ventricular (LV) remodeling.
  • The specific impact of gout on LV diastolic function remains understudied, with limited data on hyperuricemia as the sole contributor to cardiac remodeling.
  • Investigating the relationship between gout and LV diastolic function is crucial for understanding cardiovascular risks in gout patients.

Purpose of the Study:

  • To examine the effects of gout on left ventricular (LV) diastolic function.
  • To determine if gout, beyond hyperuricemia, is associated with cardiac remodeling and diastolic dysfunction.
  • To assess the relationship between serum uric acid levels, gout diagnosis, and echocardiographic parameters of cardiac function.

Main Methods:

  • 173 patients were stratified into three groups based on serum uric acid (UA) levels.
  • All participants underwent comprehensive Doppler-echocardiography to evaluate LV and left atrial (LA) volumes and function.
  • Comparison of diastolic function parameters and LV remodeling indicators between tertiles of UA levels and between gout and non-gout groups.

Main Results:

  • No significant differences in LV diastolic parameters were observed across serum UA tertiles.
  • Gout patients exhibited significantly greater LV end-systolic dimensions, LV mass index, and E/Em ratio compared to non-gout patients.
  • Patients with gout showed a higher prevalence of moderate to severe LV diastolic dysfunction and larger maximal left atrial volume index (LAVi).

Conclusions:

  • Gout, independent of hyperuricemia levels alone, is significantly associated with impaired LV diastolic function.
  • Gout is linked to left atrial enlargement, indicating potential adverse cardiac remodeling.
  • The findings underscore the importance of considering gout as an independent risk factor for cardiac dysfunction.
Abstract

More Related Videos

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

23.3K
Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse06:04

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

8.3K

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.3K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.0K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.4K
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
549
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.2K