Related Experiment Video
Updated: Mar 30, 2026
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
12.4K
Immunotherapy for Head and Neck Squamous Cell Carcinoma.
David W Schoppy1, John B Sunwoo1
1Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hematology/Oncology Clinics of North America
|November 17, 2015
Summary
Recent head and neck squamous cell carcinoma (HNSCC) research shows promising immunotherapy results. New strategies like immune checkpoint blockade and engineered T cells are being explored in early clinical trials.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Head and neck squamous cell carcinoma (HNSCC) was historically viewed as non-immunogenic.
- Emerging clinical data suggests HNSCC may respond to immunotherapeutic interventions.
Purpose of the Study:
- To review current advancements in HNSCC immunotherapy.
- To highlight novel therapeutic strategies and ongoing clinical trials.
Main Methods:
- Review of recent clinical studies on immune checkpoint blockade in HNSCC.
- Discussion of other immunotherapy approaches including antibody-dependent cell-mediated cytotoxicity enhancement, tumor vaccines, and adoptive T cell therapy.
Main Results:
- Immune checkpoint blockade strategies have shown renewed promise in HNSCC treatment.
- Several novel immunotherapy approaches are currently in early-phase clinical trials.
Conclusions:
- Immunotherapy holds significant potential for treating head and neck squamous cell carcinoma.
- Ongoing clinical trials are expected to yield exciting results in the near future.
Related Concept Videos
01:27Tumor Immunotherapy
2.2K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
02:49Cancer Therapies
10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
01:30Cancer Vaccines
1.3K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
02:57Targeted Cancer Therapies
9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.1K
02:50Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
02:56Treatment Resistent Cancers
1.5K
1.5K