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Updated: Mar 30, 2026
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A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
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Factors which affect mortality in neonatal sepsis.
Esma Ebru Turhan1, Tuğba Gürsoy1, Fahri Ovalı1
1Neonatal Intensive Care Unit, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, İstanbul, Turkey.
Turk Pediatri Arsivi
|November 17, 2015
Summary
Staphylococci were the most frequent cause of neonatal sepsis. Key mortality risk factors include low birth weight, mechanical ventilation, and parenteral nutrition.
Area of Science:
- Neonatal Intensive Care
- Infectious Diseases
- Microbiology
Background:
- Neonatal sepsis is a significant cause of newborn mortality and morbidity.
- Identifying causative agents and their resistance patterns is crucial for effective treatment.
Purpose of the Study:
- To investigate the microbiological agents responsible for neonatal sepsis.
- To analyze clinical features, antibiotic resistance, and mortality rates in a neonatal intensive care unit over a two-year period.
Main Methods:
- Retrospective analysis of patient records for newborns diagnosed with sepsis between 2010 and 2011.
- Examination of clinical data, blood, urine, and cerebrospinal fluid cultures, and antibiotic susceptibility testing.
Main Results:
- Staphylococci (Coagulase-negative Staphylococcus and Staphylococcus aureus) were the most common pathogens.
- High rates of antibiotic resistance were observed in both Gram-positive and Gram-negative bacteria.
- Low birth weight, mechanical ventilation, and parenteral nutrition were identified as significant risk factors for mortality.
Conclusions:
- Staphylococci are the predominant etiological agents in neonatal sepsis.
- Antibiotic resistance poses a considerable challenge in managing neonatal sepsis.
- Early identification and management of risk factors are essential to reduce sepsis-related mortality.
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