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Association between platelet indices and first trimester miscarriage.

Melike N Akin1, Burcu Kasap, Hilal U Yuvaci

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First trimester miscarriage risk is associated with elevated mean platelet volume (MPV) and plateletcrit. These platelet indices can help predict fetal loss in early pregnancy.

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Reproductive Medicine

Background:

  • First trimester miscarriage is a common pregnancy complication.
  • Identifying risk factors for early pregnancy loss is crucial for effective management and prevention strategies.

Purpose of the Study:

  • To investigate the association between specific hematological parameters, including mean platelet volume (MPV) and plateletcrit, and the risk of first trimester miscarriage.
  • To evaluate the predictive value of MPV and plateletcrit for identifying women at risk of early pregnancy loss.

Main Methods:

  • A case-control study involving 169 women: 78 with first trimester miscarriage and 91 controls with term deliveries.
  • Comparison of gestational age, MPV, plateletcrit, and platelet/lymphocyte ratio between cases and controls.
  • Multivariate analysis and Receiver Operating Characteristic (ROC) curve analysis to determine the predictive accuracy of MPV and plateletcrit.

Main Results:

  • Women with first trimester miscarriage had significantly higher gestational age, MPV, plateletcrit, and platelet/lymphocyte ratio compared to controls.
  • Elevated MPV (> 9.1 fl) increased miscarriage risk by 1.909 times, while elevated plateletcrit (> 0.219%) increased risk by 9.147 times.
  • MPV > 9.1 fl showed 60% sensitivity and 65% specificity; plateletcrit > 0.219% showed 64.5% sensitivity and 64.7% specificity for predicting miscarriage.

Conclusions:

  • MPV and plateletcrit are significantly associated with first trimester miscarriage.
  • These platelet indices demonstrate potential as biomarkers for predicting early pregnancy loss.
  • Platelet indices may offer a valuable tool for risk assessment and early detection of fetal loss.