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Updated: Mar 30, 2026

A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Mutational Heterogeneity in Melanoma: An Inconvenient Truth
Gregory A Chang1, David Polsky1
1The Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center, New York, New York, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, NYU Langone Medical Center, New York, New York, USA.
Abstract:
Identification of oncogenic BRAF mutations in primary and metastatic melanomas supports a linear model of clonal evolution in cancer. Some mutational studies, however, have failed to identify BRAF mutations in metastatic tumors from patients with BRAFmutant primary melanomas. Using a combination of methods, Riveiro-Falkenbach et al. (2015) assert that technical issues, and not clonal heterogeneity, may explain prior discordant mutational results.
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