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[Occupational risk factors for lung cancer]
F Delva1, P Andujar2, A Lacourt3
1Institut Bergonié, 33000 Bordeaux, France; Institut de santé publique d'épidémiologie et de développement (ISPED), université de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux cedex, France; Unité Inserm 897, université de Bordeaux, 33000 Bordeaux, France.
Revue Des Maladies Respiratoires
|November 18, 2015
Summary
Limited data exist on occupational lung carcinogens and their interaction with smoking. Primary prevention requires eliminating both occupational risks and tobacco smoke for lung cancer.
Area of Science:
- Occupational Health
- Environmental Health
- Cancer Research
Background:
- Occupational exposure to carcinogens is a known risk factor for lung cancer.
- The International Agency for Research on Cancer (IARC) classifies numerous agents as carcinogenic.
Purpose of the Study:
- To review the literature on the dose-response relationship between occupational carcinogen exposure and lung cancer risk.
- To investigate the combined effect of occupational carcinogens and tobacco exposure on lung cancer risk.
Main Methods:
- A comprehensive literature search was conducted in three databases.
- The search covered the period from January 1990 to April 2015.
- IARC monographs were also reviewed.
Main Results:
- Abundant literature exists for well-known carcinogens like asbestos, crystalline silica, and diesel exhaust fumes.
- Literature is sparse for many other occupational carcinogens.
- Data on the interaction between occupational carcinogens and tobacco exposure are particularly limited.
Conclusions:
- Most occupational lung carcinogens lack sufficient research regarding their dose-response relationship and interaction with tobacco.
- Dual primary prevention strategies are crucial, targeting both occupational risk factor elimination and tobacco smoke cessation to mitigate lung cancer risk.
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