Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis: basic concepts and hypothesis.

M Rodriguez1

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905.

Mayo Clinic Proceedings
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.

Journal of virology·1995
Same author

Epidemiology of hepatitis D virus infection: changes in the last 14 years.

The American journal of gastroenterology·1995
Same author

Comparison of Z and multivariate statistical brain electromagnetic maps for the localization of brain lesions.

Electroencephalography and clinical neurophysiology·1995
Same author

Lethality and survival of Klebsiella oxytoca evoked by conjugative IncN group plasmids.

Journal of bacteriology·1995
Same author

Predicting malignancy grade with PET in non-Hodgkin's lymphoma.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1995
Same author

Idiopathic dialysis ascites in the nineties: resolution after renal transplantation.

American journal of kidney diseases : the official journal of the National Kidney Foundation·1995
Same journal

37-Year-Old Woman With Jaundice.

Mayo Clinic proceedings·2026
Same journal

34-Year-Old Woman With An Unidentified Overdose.

Mayo Clinic proceedings·2026
Same journal

Use of Bronchoscopic Cryobiopsy in Evaluating Interstitial Lung Disease: Radiologic Predictors of Diagnostic Yield and Safety.

Mayo Clinic proceedings·2026
Same journal

Advancing Pulmonary Fibrosis Care: Integrating Genomic Insights Into Clinical Practice.

Mayo Clinic proceedings·2026
Same journal

RAAS Inhibition in the ICU: Stop, Continue, or Restart?

Mayo Clinic proceedings·2026
Same journal

Chronic Kidney Disease-In the Limelight, July 2026.

Mayo Clinic proceedings·2026
See all related articles

Multiple sclerosis involves central nervous system inflammation and myelin destruction. Recent research offers insights into its pathogenesis, exploring autoimmunity and immune responses against infected cells.

Area of Science:

  • Neuroimmunology
  • Neuropathology
  • Neurovirology

Background:

  • Multiple sclerosis (MS) is an inflammatory central nervous system (CNS) disease.
  • Primary characteristic is the destruction of myelin sheaths.
  • Pathogenesis remains incompletely understood, with multiple contributing factors.

Purpose of the Study:

  • To review recent advances in understanding MS pathogenesis.
  • To discuss current hypotheses regarding disease initiation and progression.
  • To propose a model for primary demyelination.

Main Methods:

  • Literature review of neuropathology, immunogenetics, neuroimmunology, and neurovirology.
  • Analysis of proposed hypotheses for MS development.
  • Synthesis of findings into a potential pathogenic paradigm.

Related Experiment Videos

Main Results:

  • Exploration of autoimmunity, bystander demyelination, and immune destruction of infected oligodendrocytes.
  • Proposed model involves immune cell recognition of foreign antigens on oligodendrocytes.
  • This recognition occurs within the context of major histocompatibility complex (MHC) gene products.

Conclusions:

  • The proposed paradigm suggests immune recognition of oligodendrocyte antigens initiates demyelination.
  • This process may lead to a "dying-back gliopathy" affecting myelin sheaths.
  • Understanding these mechanisms is crucial for developing future MS therapies.