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Updated: Mar 30, 2026
Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
Surface fluid-swellable chitosan fiber as the wound dressing material
Guixue Xia1, Xuqian Lang1, Ming Kong1
1College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, PR China.
Abstract:
The objective of this study was to develop a novel surface fluid-swellable chitosan (SFSC) fiber for potential wound dressing. The SFSC fiber was successfully prepared by surface modification of chitosan fiber with succinic anhydride, which was characterized by FTIR and solid-state (13)C NMR. The SFSC fiber exhibited better water absorption capacity (approx. 2980%) and stronger antibacterial activities (both above 90%) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) than chitosan fiber (both below 75%). The cell viability was more than 90% after treated with the SFSC fiber extract, which demonstrated that SFSC fiber had low cytotoxicity towards mouse embryo fibroblasts (MEFs). The SFSC fiber could promote wound healing with advanced development of granulation tissue and epithelial coverage compared with the control (gauze-covered) group. The results indicated that SFSC fiber had great potential to be used as wound dressing material.
