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Environmental enteropathy.

Asad Ali1, Najeeha T Iqbal, Kamran Sadiq

  • 1aDepartment of Paediatrics and Child Health bDepartment of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

Current Opinion in Gastroenterology
|November 18, 2015
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Summary
This summary is machine-generated.

Environmental enteropathy, a key factor in childhood malnutrition in developing nations, is being re-examined. Research is exploring new biomarkers and interventions to improve diagnosis and treatment for this condition.

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Area of Science:

  • Pediatric Gastroenterology
  • Nutritional Science
  • Global Health

Background:

  • Environmental enteropathy is a significant contributor to chronic malnutrition in children in developing countries.
  • Renewed interest stems from a focus on improving quality of life, not just survival.
  • Current understanding relies on older studies, with new histopathologic data pending.

Purpose of the Study:

  • To provide an overview of recent scientific literature on environmental enteropathy.
  • To present a perspective on the current understanding and future directions of research.
  • To summarize ongoing efforts in biomarker discovery and intervention.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of existing data on diagnostic challenges and biomarker utility.
  • Summary of conducted interventional studies.

Main Results:

  • Diagnosis of environmental enteropathy is challenging, with intestinal biopsy as the gold standard.
  • Various biomarkers are being investigated as proxies for environmental enteropathy and malnutrition, but no single ideal biomarker has emerged.
  • Initial interventional studies targeting environmental enteropathy have shown some promise.

Conclusions:

  • Basic histopathology is defined, with advanced pathophysiology studies underway.
  • Multiple biomarkers are being validated to represent different disease mechanisms.
  • A few promising interventions for environmental enteropathy are being summarized.