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[Clinical features and prognostic factors in children with fulminant myocarditis]

Liang Pei1, Ni Yang, Yu-Hang Yang

  • 1Department of Pediatric Intensive Care Unit, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China. liucf@sj-hospital.org.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|November 18, 2015
PubMed

Insights

Fulminant myocarditis in children lacks specific symptoms. A reduced left ventricular ejection fraction (LVEF) is a significant risk factor for a poor prognosis in pediatric fulminant myocarditis cases.

Area of Science:

  • Pediatric Cardiology
  • Critical Care Medicine
  • Infectious Diseases

Context:

  • Fulminant myocarditis is a severe inflammation of the heart muscle in children.
  • Early identification of prognostic factors is crucial for timely intervention and improved outcomes.
  • This study retrospectively analyzed clinical data of pediatric patients diagnosed with fulminant myocarditis.

Purpose:

  • To investigate the clinical characteristics of fulminant myocarditis in children.
  • To identify clinical features and laboratory markers associated with prognosis.
  • To determine risk factors influencing mortality in pediatric fulminant myocarditis.

Summary:

  • The study analyzed 24 children with fulminant myocarditis, classifying them into survival (n=12) and death (n=12) groups.
  • Initial symptoms varied, including gastrointestinal and neurological presentations. Elevated cardiac biomarkers (CK-MB, Troponin I, BNP) and reduced left ventricular ejection fraction (LVEF) were common.
  • Lower LVEF and higher peak serum BNP levels were observed in the non-survival group. Multivariate analysis identified decreased LVEF as a significant risk factor for poor prognosis (OR=7.418; P<0.05).

Impact:

  • Fulminant myocarditis in children presents with diverse, non-specific clinical features.
  • A decreased left ventricular ejection fraction (LVEF) is a critical indicator of poor prognosis in pediatric fulminant myocarditis.
  • Findings aid in risk stratification and management strategies for children with this life-threatening condition.
Abstract

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