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Improvement of Left Ventricular Asynchrony: Cases of Functional Recovery After Revascularization

Takanaga Niimi1, Hisatoshi Maeda2, Mamoru Nanasato3

  • 1Department of Radiological Technology, Nagoya Daini Red Cross Hospital, 2-9 Myouken-cho, Showa-Ku, Nagoya, 466-8650, Japan. nim@nagoya2.jrc.or.jp.

Cardiovascular Engineering and Technology
|November 19, 2015
PubMed

Insights

The synchronous contraction index (SCI) effectively assesses cardiac function in coronary artery disease (CAD) patients. This index improves after revascularization, indicating recovery of myocardial contraction synchronicity.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Regional contraction assessment is crucial for diagnosing coronary artery disease (CAD).
  • Evaluating myocardial contraction synchronicity and its recovery post-revascularization is important for patient management.

Purpose of the Study:

  • To evaluate myocardial contraction synchronicity using the synchronous contraction index (SCI).
  • To assess the recovery of contraction insufficiency after revascularization in CAD patients.

Main Methods:

  • Myocardial contraction was quantified using quantification of segmental function by solving the Poisson equation (QSFP) from electrocardiogram (ECG)-gated technetium-99m-methoxyisobutylisonitrile (MIBI) single-photon emission computed tomographic (SPECT) images.
  • The synchronous contraction index (SCI), defined as the temporal correlation coefficient between left ventricular (LV) volume and regional myocardial shortening, was calculated.
  • SCI was assessed in 10 CAD patients and 10 normal subjects, with ECG-SPECT performed before and after revascularization in CAD patients.

Main Results:

  • CAD patients exhibited significantly lower mean SCI (62.7 ± 19.1%) compared to normal subjects (95.0 ± 3.0%, p = 0.002).
  • Revascularization led to a significant improvement in SCI in CAD patients (74.8 ± 11.1%, p = 0.01).
  • Territorial improvement in SCI was observed (12.0 ± 15.6%, p = 0.03), and QSFP delineated abnormal cardiac contraction locations.

Conclusions:

  • The synchronous contraction index (SCI) is a valuable tool for assessing cardiac function in patients with coronary artery disease.
  • SCI demonstrates significant improvement after revascularization, reflecting recovery of myocardial contraction synchronicity.
  • QSFP effectively delineates abnormal cardiac contraction regions associated with CAD.

Keywords:
Cardiac imagingCoronary revascularizationLeft ventricular asynchronyNuclear medicineSingle-photon emission computed tomography

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