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Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
Published on: June 4, 2020
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Glia in mammalian development and disease.
J Bradley Zuchero1, Ben A Barres2
1Department of Neurobiology, Stanford University, School of Medicine, Stanford, CA 94305, USA brad.zuchero@gmail.com.
Development (Cambridge, England)
|November 19, 2015
Summary
Glia are crucial cells in the mammalian nervous system, playing key roles in development, plasticity, and disease. This review covers glial origins and their diverse functions throughout life and in various conditions.
Area of Science:
- Neuroscience
- Cell Biology
Background:
- Glia constitute over half of mammalian nervous system cells.
- Recent research highlights novel glial functions in development, plasticity, and disease.
Purpose of the Study:
- To review the origins of glia.
- To discuss the diverse roles of glia in the nervous system.
Main Methods:
- Literature review of glial cell research.
- Synthesis of findings on glial development, adult function, and disease roles.
Main Results:
- Glia originate from specific developmental pathways.
- Glia exhibit varied functions during nervous system development.
- Glia are implicated in adult nervous system plasticity and disease pathogenesis.
Conclusions:
- Glia are essential components of the mammalian nervous system.
- Understanding glial origins and functions is critical for addressing neurological disorders.
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