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Updated: Mar 30, 2026
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Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
Published on: January 12, 2022
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Next generation limb development and evolution: old questions, new perspectives.
1Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel CH-4058, Switzerland Aimee.Zuniga@unibas.ch.
Development (Cambridge, England)
|November 19, 2015
Summary
This review explores gene regulatory networks in vertebrate limb development. It highlights how systems biology and
Area of Science:
- Developmental Biology
- Evolutionary Biology
- Genomics
Background:
- Vertebrate limb bud development involves complex gene regulatory networks controlling cell patterning, proliferation, and differentiation.
- Understanding limb organogenesis is crucial for developmental biology and evolutionary studies.
Purpose of the Study:
- To review insights into gene regulatory networks governing limb development.
- To examine the evolutionary fin-to-limb transition and digit reductions in tetrapods.
Main Methods:
- Systems biology approaches integrating next-generation 'omics' data.
- Analysis of chromatin architecture and enhancer-promoter interactions.
- Gene network simulations using quantitative datasets.
Main Results:
- Advanced 'omics' and systems biology have deepened understanding of limb development control.
- Insights into the genetic basis of the fin-to-limb transition and digit loss.
Conclusions:
- Gene regulatory networks are central to limb development and evolution.
- Systems biology approaches provide powerful tools for dissecting complex developmental processes.
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