Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Taking diabetes risk screening to the community: Feasibility and acceptability of the FINDRISC tool in vulnerable populations in Argentina.

Journal of family medicine and primary care·2026
Same author

The Plasma Glycoprotein Milieu in the Hemato-Oncological Patient Inhibits Platelet Function.

Biomolecules·2026
Same author

Giant kelp-associated variation in coastal seawater chemistry across contrasting sites in Chile and Tasmania.

Annals of botany·2026
Same author

Molecular Mechanisms Underlying Recurrent Discrete Subaortic Stenosis: Insights from Bioinformatics Analysis of Human Tissue Samples.

The Annals of thoracic surgery·2026
Same author

Therapeutic hypothermia and in-hospital mortality in 35-week infants with encephalopathy.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Development and validation of a sensor-integrated smart driving test system for automated, scalable, and objective driver performance evaluation.

Scientific reports·2026

Related Experiment Video

Updated: Mar 30, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

11.0K

Establishing the Framework for Tissue Engineered Heart Pumps.

Mohamed A Mohamed1, Matt K Hogan1, Nikita M Patel1

  • 1Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, 3605 Cullen Blvd, Rm. 2005, Houston, TX, 77204, USA.

Cardiovascular Engineering and Technology
|November 19, 2015
PubMed
Summary

Researchers developed a tissue engineered heart pump (TEHP) using artificial heart muscle (AHM) as a natural alternative to mechanical cardiac assist devices (CADs). This bioengineered pump shows potential for future heart failure therapies.

Keywords:
Cardiac assist devicesCardiac pumpsCell cultureHeart failureTissue engineering

More Related Videos

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
12:28

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

3.3K
A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation
06:57

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

9.6K

Related Experiment Videos

Last Updated: Mar 30, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

11.0K
Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
12:28

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

3.3K
A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation
06:57

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

9.6K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Current cardiac assist devices (CADs) have limitations.
  • A need exists for natural alternatives in heart failure therapy.

Purpose of the Study:

  • To develop a framework for a tissue engineered heart pump (TEHP).
  • To create an artificial heart muscle (AHM) construct for cardiac assistance.

Main Methods:

  • Cultured neonatal rat cardiac cells on a fibrin gel to create AHM.
  • Wrapped AHM around acellular goat carotid artery (GCA) and chitosan hollow cylinder (CHC) scaffolds.
  • Evaluated cell adhesion, myocyte marker expression, and biopotential propagation.

Main Results:

  • Histology confirmed cardiac cell layer cohesion and adhesion to scaffolds (fibrin gel, GCA, CHC).
  • Myocyte markers (connexin43, α-actinin) were expressed.
  • ~2.5 Hz rhythmic action potential propagation was observed in the TEHP.

Conclusions:

  • The developed TEHP model demonstrates feasibility for bioengineered cardiac assistance.
  • Fibrin gel degradation could facilitate cell delivery to scaffolds.
  • Further development with bioreactors may lead to clinical applications of bioengineered CADs.