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Updated: Mar 30, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Establishing the Framework for Tissue Engineered Heart Pumps.

Mohamed A Mohamed¹, Matt K Hogan¹, Nikita M Patel¹

¹Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, 3605 Cullen Blvd, Rm. 2005, Houston, TX, 77204, USA.

Cardiovascular Engineering and Technology

|November 19, 2015

Summary

This summary is machine-generated.

Researchers developed a tissue engineered heart pump (TEHP) using artificial heart muscle (AHM) as a natural alternative to mechanical cardiac assist devices (CADs). This bioengineered pump shows potential for future heart failure therapies.

Keywords:

Cardiac assist devices Cardiac pumps Cell culture Heart failure Tissue engineering

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Tissue Engineering

Background:

Current cardiac assist devices (CADs) have limitations.
A need exists for natural alternatives in heart failure therapy.

Purpose of the Study:

To develop a framework for a tissue engineered heart pump (TEHP).
To create an artificial heart muscle (AHM) construct for cardiac assistance.

Main Methods:

Cultured neonatal rat cardiac cells on a fibrin gel to create AHM.
Wrapped AHM around acellular goat carotid artery (GCA) and chitosan hollow cylinder (CHC) scaffolds.
Evaluated cell adhesion, myocyte marker expression, and biopotential propagation.

Main Results:

Histology confirmed cardiac cell layer cohesion and adhesion to scaffolds (fibrin gel, GCA, CHC).
Myocyte markers (connexin43, α-actinin) were expressed.
~2.5 Hz rhythmic action potential propagation was observed in the TEHP.

Conclusions:

The developed TEHP model demonstrates feasibility for bioengineered cardiac assistance.
Fibrin gel degradation could facilitate cell delivery to scaffolds.
Further development with bioreactors may lead to clinical applications of bioengineered CADs.