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Updated: Mar 30, 2026

Deriving the Time Course of Glutamate Clearance with a Deconvolution Analysis of Astrocytic Transporter Currents
Published on: August 7, 2013
Vesicular glutamate transporters as anion channels?
1Graduate School of Brain Science, Doshisha University, Kyoto, Japan. stakamor@mail.doshisha.ac.jp.
Abstract:
Since the discovery of a putative Cl(-) channel on synaptic vesicle (SV) membranes, attempts to establish its molecular identity have proven surprisingly difficult. Recent evidence has emerged to support the idea that the vesicular glutamate transporter (VGLUT), whose main function is to concentrate the excitatory neurotransmitter glutamate into SVs, can also act as the Cl(-) permeation pathway. Here, I summarize studies investigating the putative Cl(-) channel on SVs and discuss the possible roles of VGLUT-mediated Cl(-) transport on glutamate loading.
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