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Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Published on: April 6, 2015
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WormBase 2016: expanding to enable helminth genomic research
Kevin L Howe1, Bruce J Bolt2, Scott Cain3
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK kevin.howe@wormbase.org.
Nucleic Acids Research
|November 19, 2015
Summary
WormBase now offers expanded data and tools for nematode research, including a new portal for parasitic worm genomes to aid helminth genomic studies.
Area of Science:
- Nematode biology, genetics, and genomics.
- Comparative genomics and evolutionary biology.
- Parasitic helminth research.
Background:
- WormBase is a key resource for Caenorhabditis elegans and other nematode research.
- The scope has expanded to include numerous nematode species, including parasitic ones.
- C. elegans research remains active, necessitating better data management tools.
Purpose of the Study:
- To update and expand the WormBase resource for nematode research.
- To introduce new tools for community curation and data navigation.
- To launch a dedicated portal for parasitic worm genomes.
Main Methods:
- Integration and curation of diverse nematode genomic and biological data.
- Development of enhanced web-based tools for browsing genomic features and ontologies.
- Creation of a specialized portal (WormBase ParaSite) for helminth genomic data.
Main Results:
- WormBase now covers a wider range of nematode species, from model organisms to parasites.
- New community curation tools and improved website navigation enhance data accessibility.
- WormBase ParaSite provides a centralized repository for annotated parasitic worm genomes.
Conclusions:
- WormBase continues to be a vital, evolving resource for the nematode research community.
- Enhanced tools and the new ParaSite portal significantly support genomic research on nematodes and helminths.
- The expanded WormBase resource facilitates research on both model and parasitic nematodes.
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