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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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Rare Event Detection Using Error-corrected DNA and RNA Sequencing
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Controlled processing during sequencing.

Malathi Thothathiri1, Michelle Rattinger1

  • 1Department of Speech and Hearing Science, The George Washington University, Washington DC, USA.

Frontiers in Human Neuroscience
|November 19, 2015
PubMed
Summary
This summary is machine-generated.

The left premotor-prefrontal junction (BA 44/6) is crucial for selecting responses during sequencing tasks. Neuroimaging confirms its role and increased connectivity with the cerebellum when planning competing responses.

Keywords:
BA 44/6controlinferior frontal junctionlanguageprefrontal cortexpremotor cortexsequencing

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • The frontal cortex plays a known role in sequencing across domains.
  • Neuropsychological studies implicate the left premotor-prefrontal junction (BA 44/6) in selection during sequencing.

Purpose of the Study:

  • To confirm and extend knowledge on the neural correlates of sequencing using neuroimaging.
  • To investigate the role of BA 44/6 in response selection under competition.

Main Methods:

  • Healthy adults performed sequencing tasks with visually presented stimuli (syllables, words).
  • Sequences were presented consecutively or concurrently to induce response competition.
  • Whole-brain and region of interest neuroimaging analyses were conducted.

Main Results:

  • Concurrent presentation led to greater activation in sensory, motor, somatosensory cortices, and anterior cingulate cortex compared to consecutive presentation.
  • Increased activation in left BA 44/6 correlated with behavioral response times.
  • Enhanced functional connectivity between left BA 44/6 and the cerebellum was observed during concurrent presentation.

Conclusions:

  • The findings support the role of BA 44/6 in response selection when dealing with competing representations.
  • BA 44/6 and other control regions are involved in ordering co-activated representations.
  • Increased cerebellar connectivity highlights its role in complex sequencing.