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Nutraceuticals as potential therapeutic agents for colon cancer: a review

Palaniselvam Kuppusamy1, Mashitah M Yusoff1, Gaanty Pragas Maniam1

  • 1Mammalian Cell Technology Laboratory, Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Gambang, Kuantan, Pahang, Malaysia.

Acta Pharmaceutica Sinica. B
|November 19, 2015
PubMed

Insights

Nutraceuticals, derived from natural sources, show promise in reducing colon cancer risk and progression. This review explores their medicinal importance in combating colorectal cancer.

Area of Science:

  • Oncology
  • Nutritional Science
  • Preventive Medicine

Background:

  • Colon cancer is a leading global health concern, with rising mortality linked to modern diets and lifestyles.
  • Increasing incidence necessitates novel, environmentally benign therapeutic strategies for colon cancer.
  • Nutraceuticals are emerging as key players in managing chronic diseases, including colon cancer.

Purpose of the Study:

  • To review the medicinal importance of nutraceuticals.
  • To discuss the potential of nutraceuticals in reducing colorectal cancer risk and slowing its progression.
  • To highlight nutraceuticals as natural, environmentally benign therapeutic options.

Main Methods:

  • Literature review of scientific studies on nutraceuticals and colon cancer.
  • Analysis of nutraceuticals derived from natural sources like plants, marine organisms, vegetables, and fruits.
  • Examination of molecular targets and mechanisms of action for nutraceuticals in cancer development.

Main Results:

  • Nutraceuticals demonstrate potential in mitigating colon cancer risk.
  • These natural compounds can influence various molecular pathways involved in cancer development.
  • Nutraceuticals show promise in slowing the progression of existing colon cancer.

Conclusions:

  • Nutraceuticals offer a valuable approach for reducing the risk of colorectal cancer.
  • Their natural origin and diverse mechanisms make them attractive therapeutic agents.
  • Further research into nutraceuticals can lead to innovative, eco-friendly colon cancer therapies.
Keywords:
5-FU, 5-fluorouracilACC, acetyl CoA carboxylaseACF, aberrant crypt fociACL, ATP-citrate lyaseASTX, astaxanthinCOX-2, cyclooxygenase 2Colon cancerDHA, decahexaenoic acidDMH, 1,2-dimethylhydrazineDR, death receptorEGCG, epigallocatechingallateEPA, eicosapentaenoic acidFAS, fatty acid synthaseGADD, growth arrest and DNA damageHMG-CoA, 3-hydroxy-3-methyl-glutaryl CoAHUVEC, human umbilical vein endothelial cellIGF, insulin-like growth factorIL, interleukinLDH, lactate dehydrogenaseMMP, matrix metallo-proteinsMarine organismsNF-κB, nuclear factor-kappa BNutraceuticalsPRAP, prolactin receptor associated proteinPlant derivativesTCA, tricarboxylic acid cycleTNF, tumor necrosis factorTRAIL, tumor necrosis factor-related apoptosis-induced ligandTherapeuticsVEGF, vascular endothelial growth factor

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