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Bile acid nuclear receptor FXR and digestive system diseases

Lili Ding1, Li Yang2, Zhengtao Wang2

  • 1Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China ; Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

Acta Pharmaceutica Sinica. B
|November 19, 2015
PubMed

Keywords:
6-ECDCA, 6α-ethyl-chenodeoxycholic acidAF2, activation domainANGTPL3, angiopoietin-like protein 3AOM, azoxymethaneAP-1, activator protein-1ASBT, apical sodium-dependent bile salt transporterApo, apolipoproteinBAAT, bile acid-CoA amino acid N-acetyltransferaseBACS, bile acid-CoA synthetaseBAs, bile acidsBMI, body mass indexBSEP, bile salt export pumpBile acidsCA, cholic acidCD, Crohn׳s diseaseCDCA, chenodeoxycholic acidCREB, cAMP regulatory element-binding proteinCYP7A1, cholesterol 7α-hydroxylaseColorectal cancerDBD, DNA binding domainDCA, deoxycholic acidDSS, dextrane sodium sulfateERK, extracellular signal-regulated kinaseFABP6, fatty acid-binding protein subclass 6FFAs, free fatty acidsFGF19, fibroblast growth factor 19FGFR4, fibroblast growth factor receptor 4FXR, farnesoid X receptorFXRE, farnesoid X receptor response elementFarnesoid X receptorG6Pase, glucose-6-phosphataseGLP-1, glucagon-like peptide 1GLUT2, glucose transporter type 2GPBAR, G protein-coupled BA receptorGPCRs, G protein-coupled receptorsGSK3, glycogen synthase kinase 3Gastrointestinal tractHDL-C, high density lipoprotein cholesterolHNF4α, hepatic nuclear factor 4αI-BABP, intestinal bile acid-binding proteinIBD, inflammatory bowel diseaseIL-1, interleukin 1Inflammatory bowel diseaseKLF11, Krüppel-like factor 11KRAS, Kirsten rat sarcoma viral oncogene homologLBD, ligand binding domainLCA, lithocholic acidLPL, lipoprotein lipaseLRH-1, liver receptor homolog-1MCA, muricholicacidMRP2, multidrug resistance-associated protein 2NF-κB, nuclear factor-kappa BNOD, non-obese diabeticNRs, nuclear receptorsOSTα, organic solute transporter alphaOSTβ, organic solute transporter betaPEPCK, phosphoenol pyruvate carboxykinasePGC-1α, peroxisome proliferators-activated receptor γ coactivator protein-1αSHP, small heterodimer partnerSREBP-1c, sterol regulatory element-binding protein 1cSTAT3, signal transducers and activators of transcription 3T2D, type 2 diabetesTLCA, taurolithocholic acidTNBS, trinitrobenzensulfonic acidTNFα, tumor necrosis factors αType 2 diabetesUC, ulcerative colitisUDCA, ursodeoxycholic acidVSG, vertical sleeve gastrectomydb/db, diabetic mice

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