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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism

Eric Kwong1, Yunzhou Li2, Phillip B Hylemon3

  • 1Department of Microbiology and Immunology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA.

Acta Pharmaceutica Sinica. B
|November 19, 2015
PubMed

Keywords:
ABC, ATP-binding cassetteAKT/PKB, protein kinase BBSEP/ABCB11, bile salt export proteinBile acidCA, cholic acidCBA, conjugated bile acidsCDCA, chenodeoxycholic acidCYP27A1, sterol 27-hydroxylaseCYP7A1, cholesterol 7α-hydroxylaseCYP7B1, oxysterol 7α-hydroxylaseCYP8B1, 12α-hydroxylaseDCA, deoxycholic acidEGFR, epidermal growth factor receptorERK, extracellular regulated protein kinasesFGF15/19, fibroblast growth factor 15/19FGFR, fibroblast growth factor receptorFXR, farnesoid X receptorG-6-Pase, glucose-6-phophataseGPCR, G-protein coupled receptorHDL, high density lipoproteinHNF4α, hepatocyte nuclear factor-4αHeptic lipid metabolismIBAT, ileal sodium-dependent bile acid transporterJNK1/2, c-Jun N-terminal kinaseLCA, lithocholic acidLDL, low-density lipoproteinLRH-1, liver-related homolog-1M1–5, muscarinic receptor 1–5MMP, matrix metalloproteinaseNAFLD, non-alcoholic fatty liver diseaseNK, natural killer cellsNTCP, sodium taurocholate cotransporting polypeptidePEPCK, PEP carboxykinsePTX, pertussis toxinS1P, sphingosine-1-phosphateS1PR2, sphingosine-1-phosphate receptor 2SHP, small heterodimer partnerSPL, S1P lyaseSPPs, S1P phosphatasesSRC, proto-oncogene tyrosine-protein kinaseSphK, sphingosine kinaseSphingosine-1 phosphate receptorSpns2, spinster homologue 2TCA, taurocholateTGR5, G-protein-coupled bile acid receptorTNFα, tumor necrosis factor αVLDL, very-low-density lipoprotein

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