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Study on pharmacokinetics and tissue distribution of the isocorydine derivative (AICD) in rats by HPLC-DAD method

Yali Chen1, Qian Yan2, Mei Zhong2

  • 1Institute of Medicinal Chemistry, School of Pharmacy, Lanzhou University, Lanzhou 730000, China ; Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.

Acta Pharmaceutica Sinica. B
|November 19, 2015
PubMed

Keywords:
8-Acetamino-isocorydineAICD, 8-acetamino-isocorydineAUC, area under concentration-time curveAlkaloidsF, absolute bioavailabilityHPLC-DAD, high-performance liquid chromatography with diode-array detectionHPLC-UV, high-performance liquid chromatography coupled with ultraviolet detectionHigh-performance liquid chromatography with diode-array detectionICD, isocorydineIS, internal standardLC-ESI-MS/MS, high-performance liquid chromatography–electrospray ionization–tandem mass spectrometryLLE, liquid-liquid extractionLLOQ, lower limit of quantificationLOD, limit of detectionPharmacokineticsQC, quality controlRE, relative errorRP, reverse phaseRSD, relative standard deviationSD, standard deviation.Tissue distribution

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