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Site-specific PEGylation of lidamycin and its antitumor activity

Liang Li1, Boyang Shang1, Lei Hu1

  • 1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Acta Pharmaceutica Sinica. B
|November 19, 2015
PubMed

Keywords:
ADCs, antibody drug conjugatesAE, active enediyneAnti-TNF Fab′, anti-tumor necrosis factor Fab′DMSO, dimethyl sulfoxideEnediyne antibioticG-CSF, granulocyte colony stimulating factorIC50 values, half-inhibitory concentrationsIFN, interferonIPTG, isopropyl-β-d-thiogalactosideLB, Luria-BertaniLDM, lidamycinLidamycinPEG, polyethyleneglycolPolyethylene glycolSEC-HPLC, size-exclusion high-performance liquid chromatographySite-specific PEGylationmPEG-ALD, methoxy-PEG-propionaldehyderLDP, recombinant lidamycin apoproteinrhG-CSF, recombinant human granulocyte colony stimulating factor

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