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Calycosin-7-O-β-d-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling

Jing Jian1, Lijuan Sun1, Xun Cheng1

  • 1Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei University, Wuhan 430062, China.

Acta Pharmaceutica Sinica. B
|November 19, 2015
PubMed

Keywords:
ALP, alkaline phosphataseAR, Astragalus membranaceusBMP signaling pathwayBMP, bone morphogenetic proteinCG, calycosin-7-O-β-d-glucopyranosideCalycosin-7-O-β-d-glucopyranosideDKK-1, dickkopf-1ECL, enhanced chemiluminescenceFGF, fibroblast growth factorHAase, hyaluronidaseIGF1, insulin-like growth factor 1MAPK, mitogen-activated protein kinaseMTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromideOBM, osteogenic differentiation mediumOPN, osteopontinOVX, ovariectomizedOcal, osteocalcinOsteoblastic differentiationPVDF, polyvinylidine fluorideST2 cellsTGF-β, transforming growth factor βWNT, wingless-type MMTV integration site familyWNT/β-catenin signaling pathway

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