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Related Concept Videos

Maxam-Gilbert Sequencing01:05

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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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Related Experiment Video

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Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels
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Multitriggered Shape-Memory Acrylamide-DNA Hydrogels.

Chun-Hua Lu1, Weiwei Guo1, Yuwei Hu1

  • 1The Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.

Journal of the American Chemical Society
|November 19, 2015
PubMed
Summary
This summary is machine-generated.

Researchers developed shape-memory hydrogels from acrylamide-DNA that can switch between stiff, shaped forms and soft, shapeless states. These smart materials offer potential for advanced applications in sensing and information storage.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biotechnology

Background:

  • Hydrogels are versatile materials with tunable properties.
  • Stimuli-responsive polymers can undergo reversible changes in response to external triggers.
  • Developing materials with shape-memory capabilities is crucial for advanced applications.

Purpose of the Study:

  • To create novel acrylamide-DNA hydrogels with shape-memory properties.
  • To investigate the stimuli-responsive transitions between shaped and shapeless states.
  • To explore the potential applications of these shape-memory hydrogels.

Main Methods:

  • Cross-linking of acrylamide-nucleic acids using cooperative functional motifs.
  • Incorporation of stimuli-responsive bridges (e.g., K(+)-stabilized G-quadruplexes/duplex, i-motif/duplex).
  • Cyclic application of triggers and counter-triggers (K(+) ion/crown ether, pH changes, fuel/antifuel strands) to induce shape transitions.

Main Results:

  • Demonstrated reversible transitions between stiff shaped hydrogels and soft shapeless states.
  • Showcased intrinsic shape memory due to chain entanglement after dissociation of stimuli-responsive bridges.
  • Successfully integrated hydrogels into hybrid structures with programmable domain transitions.

Conclusions:

  • Acrylamide-DNA hydrogels exhibit controllable shape-memory behavior.
  • Stimuli-responsive cross-linking enables reversible shape switching.
  • These materials hold promise for applications in sensing, information inscription, and controlled release.