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Published on: January 9, 2017
Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine
Chun-Qiong Zhou1, Jian-Wei Yang, Cheng Dong
1Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China. whchen@smu.edu.cn.
Abstract:
This paper describes the highly selective, sensitive and topology-specific fluorescent sensing of dimeric G-quadruplexes by a polyether-tethered dimeric berberine 1. Compound 1 displays high selectivity for dimeric G-quadruplexes over monomeric ones, and can be lit up by dimeric G-quadruplexes, in particular by the one linked with one TTA subunit. In addition, it shows no effect on the topology or thermal stability of the G-quadruplexes.
