Related Experiment Video
Updated: Mar 30, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
13.1K
Human Endogenous Retrovirus Expression in Primary Cutaneous T-Cell Lymphomas
Paolo Fava1, Massimiliano Bergallo, Chiara Astrua
1Section of Dermatology, Department of Medical Sciences, Medical School, University of Turin, Turin, Italy.
Dermatology (Basel, Switzerland)
|November 19, 2015
Summary
Human endogenous retroviruses (HERVs) are overexpressed in cutaneous T-cell lymphomas (CTCL), including mycosis fungoides (MF) and Sézary syndrome (SS). This study found no difference in HERV expression between early and advanced CTCL stages.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T-cell lymphomas (CTCL).
- Human endogenous retroviruses (HERVs) are integrated into primate DNA and can be reactivated by stimuli.
- Limited data exist on HERV expression in CTCL.
Purpose of the Study:
- To investigate the endogenous retroviral transcription profile in CTCL.
- To assess HERV expression across different clinical stages of CTCL.
Main Methods:
- Analysis of peripheral blood mononuclear cells from 42 MF/SS patients.
- RNA extraction and amplification using reverse transcription polymerase chain reaction.
- Comparison of results with 20 healthy donors.
Main Results:
- Significant overexpression of HERVs was observed in MF/SS patients compared to healthy donors.
- No significant differences in HERV expression were detected between early and advanced CTCL stages.
Conclusions:
- HERVs may play a role as promoters in the pathogenesis of MF/SS.
- Further research is needed to correlate HERV overexpression with patient outcomes in CTCL.
More Related Videos
Related Concept Videos
03:18Non-LTR Retrotransposons
14.0K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
14.0K
01:51Mechanisms of Retrovirus-induced Cancers
7.2K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.2K