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On the Origin of Sequence.

Peter T S van der Gulik1

  • 1Centrum Wiskunde & Informatica, P.O.Box 94079, 1090 GB Amsterdam, The Netherlands. Peter.van.der.Gulik@cwi.nl.

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Summary
This summary is machine-generated.

The peptide GlyGly may have been life's original product, stimulating peptide bonds and protecting RNA. This feedback loop involving RNA and GlyGly is proposed as fundamental to life's emergence.

Keywords:
error robustnessgenetic codeorigin of lifepeptidesprebiotic processes

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Area of Science:

  • Astrobiology
  • Origin of Life Studies
  • Biochemistry

Background:

  • Earth's unique conditions (mineralogy, Moon, triple environment) are crucial for peptide emergence.
  • The peptide GlyGly uniquely catalyzes peptide bond formation in Salt-Induced Peptide Formation.
  • Glycine and aspartic acid play significant roles in RNA polymerase active sites.

Purpose of the Study:

  • To propose GlyGly as a potential original product of coded peptide synthesis.
  • To elucidate the role of GlyGly in early life development and RNA protection.
  • To present a feedback loop involving RNA and GlyGly as fundamental to life's origin.

Main Methods:

  • Analysis of peptide formation reactions.
  • Investigation of the role of specific amino acids (glycine, aspartic acid) in biological processes.
  • Examination of the structure of the genetic code for historical information.

Main Results:

  • GlyGly stimulates oligopeptide production, particularly those rich in aspartic acid.
  • Aspartic acid-rich peptides protect small RNA molecules by binding Mg2+ ions.
  • A feedback loop where RNA produces GlyGly is proposed as essential for life.
  • The genetic code's structure contains historical information about life's emergence.

Conclusions:

  • GlyGly's catalytic and protective roles suggest it was fundamental to early life.
  • The proposed RNA-GlyGly feedback loop is a key element in the origin of life.
  • The genetic code's structure reflects the historical pathway of life's emergence.