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Colic in infants
1Department of General Practice, Radboud University Nijmegen, Nijmegen, The Netherlands.
Insights
This systematic overview evaluates treatments for infant colic, a common issue affecting 17% of families. It categorizes the efficacy of seven interventions, including specialized milks and therapies, to inform clinical practice.
Area of Science:
- Pediatrics
- Gastroenterology
- Evidence-Based Medicine
Background:
- Infant colic affects 17% of families, often leading to healthcare consultations.
- Prevalence varies significantly based on study design and recording methods.
Purpose of the Study:
- To systematically review the effects of various treatments for infant colic.
- To answer the clinical question regarding the efficacy and safety of colic interventions.
Main Methods:
- Conducted a systematic overview of existing literature.
- Searched major databases (Medline, Embase, Cochrane Library) up to February 2014.
- Included systematic reviews and randomized controlled trials (RCTs), performing GRADE evaluations.
Main Results:
- Screened 22 records for inclusion, evaluating 12 full publications.
- Added three systematic reviews and four RCTs at this update.
- Performed GRADE evaluation for six PICO combinations.
Conclusions:
- Categorized the efficacy of seven interventions for infant colic.
- Interventions evaluated include specialized infant feeds (casein/whey hydrolysate, low-lactose, soya-based) and therapies (cranial osteopathy, Lactobacillus reuteri, spinal manipulation).
Introduction:
Colic in infants leads one in six families (17%) with children to consult a health professional. One systematic review of 15 community-based studies found a wide variation in prevalence, which depended on study design and method of recording.
Methods And Outcomes:
We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of treatments for colic in infants? We searched: Medline, Embase, The Cochrane Library, and other important databases up to February 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview).
Results:
At this update, searching of electronic databases retrieved 47 studies. After deduplication and removal of conference abstracts, 22 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 10 studies and the further review of 12 full publications. Of the 12 full articles evaluated, three systematic reviews and four RCTs were added at this update. We performed a GRADE evaluation for six PICO combinations.
Conclusions:
In this systematic overview, we categorise the efficacy for seven interventions based on information relating to the effectiveness and safety of casein hydrolysate milk, cranial osteopathy, Lactobacillus reuteri (probiotic), low-lactose milk, soya-based infant feeds, spinal manipulation, and whey hydrolysate milk.
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