Related Experiment Video

Updated: Mar 30, 2026

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
08:42

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

2.7K

Novel avenues in immunotherapies for colorectal cancer

Iris N Pardieck1, Priscilla A Jawahier1, Marloes Swets1

  • 1a Department of Surgery , Leiden University Medical Center , Leiden , The Netherlands.

Expert Review of Gastroenterology & Hepatology
|November 20, 2015
PubMed

Insights

Cancer immunotherapy shows promise but faces limitations due to tumor cells evading immune control. New therapies are emerging to address these tumor-immune escape mechanisms for improved cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • The immune system plays a critical role in regulating tumor growth.
  • Cancer immunotherapy has emerged as a promising therapeutic strategy.
  • Understanding tumor-immune interactions is crucial for advancing cancer treatment.

Purpose of the Study:

  • To explore the development of immunotherapy to combat cancer.
  • To investigate the limitations of current immunotherapy approaches.
  • To identify new therapeutic strategies targeting tumor-immune escape.

Main Methods:

  • Review of existing knowledge on tumor-immune interactions.
  • Analysis of the mechanisms behind tumor immune escape.
  • Examination of emerging therapies designed to overcome immune evasion.

Main Results:

  • Immunotherapy has shown some successes in cancer treatment.
  • Tumor cells can develop resistance to immune control through spontaneous genetic alterations.
  • Tumor-immune escape represents a significant limitation for current immunotherapy.

Conclusions:

  • Despite successes, cancer immunotherapy faces challenges due to tumor immune escape.
  • New therapeutic approaches are being developed to overcome these escape mechanisms.
  • Further research into tumor-immune interactions is essential for effective cancer immunotherapy.
Keywords:
CRCcancer immunoeditingclinical trialscolorectal cancerimmune systemimmunotherapytumor microenvironment

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

14.6K
Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer06:19

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Published on: July 18, 2017

10.9K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
669
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K